Centre Armand Frappier Santé Biotechnologie
Journal Articles
100. Structure-Based Optimization and Biological Evaluation of SARS-CoV-2 3CLpro Covalent Inhibitors
Guanyu Wang, Julia Stille, Richard Boulon, Christopher Hennecker, Xiaocong Zhang, Nicole Blaine, Steven Laplante, Anthony Mittermaier, Nicolas Moitessier; ACS Pharmacology, 25 Oct 2024 doi:10.26434/chemrxiv-2024-091mt
David Bendahan, Tanos Celmar Costa Franca, Kathleen Amiens, Yann Ayotte, Pat Forgione, Steven LaPlante; New Journal of Chemistry, 2 Oct 2024 doi:10.1039/D4NJ00727A
98. Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy
Maxime Mistretta, Mena Cimino, Pascal Campagne, Stevenn Volant, Etienne Kornobis, Olivier Hebert, Christophe Rochais, Patrick Dallemagne, Cédric Lecoutey, Camille Tisnerat, Alban Lepailleur, Yann Ayotte, Steven R. LaPlante, Nicolas Gangneux, Monika Záhorszká, Jana Korduláková, Sophie Vichier-Guerre, Frédéric Bonhomme, Laura Pokorny, Marvin Albert, Jean-Yves Tinevez & Giulia Manina; 16 May 2024
doi:10.1038/s41467-024-48269-2
97. Molecular Dynamics of Outer Membrane-Embedded Polysaccharide Secretion Porins Reveals Closed Resting-State Surface Gates Targetable by Virtual Fragment Screening for Drug Hotspot Identification
Tanos Celmar Costa França, Fares Saïdi, Alain Ajamian, Salim T. Islam and Steven R. LaPlante; ACS Omega, 4 March 2024doi:10.1021/acsomega.3c09970
96.The Search for Antidotes Against Ricin
Fernanda Diniz Botelho, Tanos Celmar Costa Franca* and Steven R. LaPlante; Bentham Sciences, 2024 Jan 23, doi:10.2174/0113895575270509231121060105
95. NMR Spectroscopy Can Help Accelerate Antiviral Drug Discovery Programs
Steven R Laplante, Pascale Coric, Serge Bouaziz, Tanos Celmar Costa França. Microbes and Infection 2024 Jan 09. doi:10.16/j.micinf.2024.105297
94. Arylboronic acids as safe and specific human butyrylcholinesterase inhibitors
Eduardo Mendes dos Santos, Nayane Abreu do Amaral e Silva, Karina Godarth Gonçalves, André Alvares Marques Vale, Ana Paula Silva de Azevedo-Santos, Tanos Celmar Costa França, Steven R LaPlante, Jackson Antonio Lamounier Camargos Resende, Nelilma Correia Romeiro, Josélia Alencar Lima, Daniela de Luna Martins, Maria do Desterro Soares Brandão Nascimento; 2023 Oct 15 doi.org/10.1016/j.molstruc.2023.135932
93. Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings
Ahmed Fnaiche, Léa Mélin, Narjara González Suárez, Alexis Paquin, Victoria Vu, Fengling Li, Abdellah Allali-Hassani, Albina Bolotokova, Frédéric Allemand, Muriel Gelin, Philippe Cotelle, Simon Woo, Steven R LaPlante, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Masoud Vedadi, Jean-François Guichou, Borhane Annabi, Alexandre Gagnon.
Bioorganic & medicinal chemistry letters. 2023 Oct 15. doi:10.1016/j.bmcl.2023.129488
92. Robust Strategy for Hit-to-Lead Discovery: NMR for SAR
Sacha T Larda, Yann Ayotte, Maria M Denk, Paul Coote, Gregory Heffron, David Bendahan, Fatma Shahout, Nicolas Girard, Mustapha Iddir, Patricia Bouchard, Francois Bilodeau, Simon Woo, Luc J Farmer, Steven R LaPlante.Journal of medicinal chemistry. 2023 Sept 21. doi:10.1021/acs.jmedchem.3c00656
91. Molecular modeling of Mannich phenols as reactivators of human acetylcholinesterase inhibited by A-series nerve agents
Leandro A Vieira, Joyce SFD Almeida, Martijn C De Koning, Steven R LaPlante, Itamar Borges Jr, Tanos CC França. Chemico-biological interactions. 2023 Sept 1. doi:10.1016/j.cbi.2023.110622
90. A Multi-epitope Vaccine Candidate Against Bolivian Hemorrhagic fever Caused by Machupo Virus
Zeeshan Ali, Jyothsna Volisha Cardoza, Srijita Basak, Utkarsh Narsaria, Surjit Bhattacharjee, Samuel Paul Isaac, Tanos CC Franca, Steven R LaPlante, Sudhan S George. Applied biochemistry and biotechnology. 2023 Jul 22. doi:10.1007/s12010-023-04604-9
89. Determining the Predominant Conformations of Mortiamides A–D in Solution Using NMR Data and Molecular Modeling Tools
Tanos CC Franca, Arlan da Silva Goncalves, Christopher Bérubé, Normand Voyer, Norman Aubry, Steven R LaPlante. ACS Omega. 2023 Jul. 8 doi:10.1021/acsomega.3c01206
88. Drug Self-Aggregation into Nano-Entities Has the Potential to Induce Immune Responses.
Fatma Shahout, Marion Vanharen, Abdelaziz Saafane, James Gillard, Denis Girard, Steven R LaPlante. Molecular pharmaceutics. 2023 Jul 8.. doi:10.1021/acs.molpharmaceut.3c00196.
87. Computational design of candidate multi-epitope vaccine against SARS-CoV-2 targeting structural (S and N) and non-structural (NSP3 and NSP12) proteins.
Eduardo Mendes dos Santos, Nayane Abreu do Amaral Silva, Karina Godarth Gonçalves , André Alvares Marques Vale, Ana Paula Silva de Azevedo-Santos, Tanos Celmar Costa França, Steven R. LaPlante, Jackson Antonio Lamounier Camargos Resende , Nelilma Correia Romeiro, Josélia Alencar Lima, Daniela de Luna Martins, Maria do Desterro Soares Brandão Nascimento .J Mol.Struct. 2023 Jun 2. .doi: 10.1016/j.molstruc.2023.135932.
86. Molecular modeling study of natural products as potential bioactive compounds against SARS-CoV-2
Rayssa Ribeiro, Fernanda D Botelho, Amanda MV Pinto, Antonia MA La Torre, Joyce SFD Almeida, Steven R LaPlante, Tanos CC Franca, Valdir F Veiga-Junior, Marcelo C Dos Santos. J. of Mol. Mod. 2023 May 22 . doi: 10.1007/s00894-023-05586-5.
85. Computational design of candidate multi-epitope vaccine against SARS-CoV-2 targeting structural (S and N) and non-structural (NSP3 and NSP12) proteins.
Ali Z, Cardoza JV, Basak S, Narsaria U, Singh VP, Isaac SP, França TCC, LaPlante SR, George SS.J Biomol Struct Dyn. 2023 Feb 6:. doi: 10.1080/07391102.2023.2173297.
84. N-Phenylpyridine-3-Carboxamide and 6-Acetyl-1H-Indazole Inhibit the RNA Replication Step of the Dengue Virus Life Cycle.
Sow AA, Pahmeier F, Ayotte Y, Anton A, Mazeaud C, Charpentier T, Angelo L, Woo S, Cerikan B, Falzarano D, Abrahamyan L, Lamarre A, Labonté P, Cortese M, Bartenschlager R, LaPlante SR, Chatel-Chaix L.Antimicrob Agents Chemother. 2023 Feb 16;67(2):e0133122. doi: 10.1128/aac.01331-22.
83. Modeling studies on the role of vitamins B1 (thiamin), B3 (nicotinamide), B6 (pyridoxamine), and caffeine as potential leads for the drug design against COVID-19.
Aghamohammadi M, Sirouspour M, Goncalves AS, França TCC, LaPlante SR, Shahdousti P.J Mol Model. 2022 Nov 7;28(12):380. doi: 10.1007/s00894-022-05356-9.PMID: 36342543
82. Theoretical Investigation of Repurposed Drugs Potentially Capable of Binding to the Catalytic Site and the Secondary Binding Pocket of Subunit A of Ricin.
França TCC, Botelho FD, Drummond ML, LaPlante SR.ACS Omega. 2022 Aug 26;7(36):32805-32815. doi: 10.1021/acsomega.2c04819. eCollection 2022 Sep 13.PMID: 36120038
81. Are the current commercially available oximes capable of reactivating acetylcholinesterase inhibited by the nerve agents of the A-series?
Santos MC, Botelho FD, Gonçalves AS, Kitagawa DAS, Borges CVN, Carvalho-Silva T, Bernardo LB, Ferreira CN, Rodrigues RB, Ferreira Neto DC, Nepovimova E, Kuča K, LaPlante SR, Lima ALS, França TCC, Cavalcante SFA.Arch Toxicol. 2022 Sep;96(9):2559-2572. doi: 10.1007/s00204-022-03316-z.
80.Practical Considerations and Guidelines for Spectral Referencing for Fluorine NMR Ligand Screening.
Ayotte Y, Woo S, LaPlante SR.ACS Omega. 2022 Apr 6;7(15):13155-13163. doi: 10.1021/acsomega.2c00613. eCollection 2022 Apr 19.PMID: 35474811
79. Jumping from Fragment to Drug via Smart Scaffolds.
Farahani MD, França TCC, Alapour S, Shahout F, Boulon R, Iddir M, Maddalena M, Ayotte Y, LaPlante SR.ChemMedChem. 2022 May 18;17(10):e202200092. doi: 10.1002/cmdc.202200092.
78. Fragment-Based Phenotypic Lead Discovery To Identify New Drug Seeds That Target Infectious Diseases.
Ayotte Y, Bernet E, Bilodeau F, Cimino M, Gagnon D, Lebughe M, Mistretta M, Ogadinma P, Ouali SL, Sow AA, Chatel-Chaix L, Descoteaux A, Manina G, Richard D, Veyrier F, LaPlante SR.ACS Chem Biol. 2021 Nov 19;16(11):2158-2163. doi: 10.1021/acschembio.1c00657.
77. Development of LM98, a Small-Molecule TEAD Inhibitor Derived from Flufenamic Acid.
Mélin L, Abdullayev S, Fnaiche A, Vu V, González Suárez N, Zeng H, Szewczyk MM, Li F, Senisterra G, Allali-Hassani A, Chau I, Dong A, Woo S, Annabi B, Halabelian L, LaPlante SR, Vedadi M, Barsyte-Lovejoy D, Santhakumar V, Gagnon A.ChemMedChem. 2021 Oct 6;16(19):2982-3002. doi: 10.1002/cmdc.202100432.
76. Docking and molecular dynamics studies of potential new leads against DBL3x derived from chondroitin sulfate A (CSA): a new approach for the treatment of malaria
Joao P. M. Spadeto, Rodrigo A. Cormanich, Tanos C. C. Franca, Steven R. LaPlante & Arlan S. Goncalves (2021) Journal of Biomolecular Structure and Dynamics, DOI: 10.1080/07391102.2021.1911859
75. Docking and molecular dynamics studies of potential new leads against DBL3x derived from chondroitin sulfate A (CSA): a new approach for the treatment of malaria
Joao P. M. Spadeto, Rodrigo A. Cormanich, Tanos C. C. Franca, Steven R. LaPlante & Arlan S. Goncalves (2021) Journal of Biomolecular Structure and Dynamics, DOI: 10.1080/07391102.2021.1911859
74. Sodium Tetraphenylborate Displays Selective Bactericidal Activity against Neisseria meningitidis and N. gonorrhoeae and Is Effective at Reducing Bacterial Infection Load
Eve Bernet, Marthe Lebughe, Antony T. Vincent, Mohammad Mehdi Haghdoost, Golara Golbaghi, Steven Laplante, Annie Castonguay, Frederic J. Veyrier
Antimicrobial Agents and Chemotherapy Jan 2021, 65 (2) e00254-20; DOI: 10.1128/AAC.00254-20
73. Identification of novel potential ricin inhibitors by virtual screening, molecular docking, molecular dynamics and MM-PBSA calculations: a drug repurposing approach
Botelho, F.D.; Santos, M.C; Gonçalves, A.S.; França, T.C.C.; LaPlante, S.R.; de Almedia, J.S.F.D.
Journal of Biomolecular Structure and Dynamics, DOI: 10.1080/07391102.2020.1870154
72. Searching for potential drugs against SARS-CoV-2 through virtual screening on several molecular targets
Joyce S. F. D. Almeida , Fernanda D. Botelho , Felipe R. de Souza , Marcelo C. dos Santos , Arlan da Silva Goncalves , Rodrigo L. B. Rodrigues , Monique Cardozo , Daniel
A. S. Kitagawa , Leandro A. Vieira , Raphael S. F. Silva , Samir F. A. Cavalcante , Leonardo da C. Bastos , Mariana de O. T. Nogueira , Priscila I. R. de Santana , Juliana de O. C. Brum , Eugenie Nepovimova , Kamil Kuca , Steven R. LaPlante , Erick B. F. Galante & Tanos C. C. Franca ,Journal of Biomolecular Structure and Dynamics, DOI: 10.1080/07391102.2020.1869096
71. Synthesis and Biological Activity of Hydrazones and Derivatives
Juliana de Oliveira Carneiro Brum1,*, Tanos Celmar Costa França2,3,4, Steven R. LaPlante4 and José Daniel Figueroa Villar, 2020, 20,342-368 , doi:10.2174/1389557519666191014142448
70. Ligand-Based Virtual Screening, Molecular Docking, Molecular Dynamics, and MM-PBSA Calculations towards the Identification of Potential Novel Ricin Inhibitors
Botelho, FD; dos Santos , M.C; Gonçalves, A.S; Kuca, K; Valis, M; LaPlante, S.R.; França, T.C.C; and de Almeida, J.S.F.D.
Toxins 2020, 12, 746; doi:10.3390/toxins12120746
69. Structure-thermodynamics-relationships of hepatitis C viral NS3 protease inhibitors
Wypych, R. M.; LaPlante, S. R.; White, P. W.; Martin, S. F. Eur. J. Med. Chem. 2020, 192, 112195.
68. Reactivation of VX-Inhibited Human Acetylcholinesterase by Deprotonated Pralidoxime. A Complementary Quantum Mechanical Study
da Silva, J. A. V.; Pereira, A. F.; Laplante, S. R.; Kuca, K.; Ramalho, T. C.; França, T. C. C. Biomolecules 2020, 10 (2), 192.
67. Exposing Small-molecule Nano-entities By An NMR Relaxation Assay
Ayotte,Y.; Marando,V.M.; Vaillancourt,L.; Bouchard,P.; Heffron,G.; Coote,P.W.; Larda,S.T.; LaPlante,S.R.
J. Med. Chem. 2019, 62, 17, 7885–7896 https://doi.org/10.1021/acs.jmedchem.9b00653
66. Revealing Drug Self-Associations into Nano-Entities
Dlim, M. M.; Shahout, F. S.; Khabir, M. K.; Labonté, P. P.; LaPlante, S. R. ACS Omega 2019, 4 (5), 8919–8925.
65. Synthesis of NSC 106084 and NSC 14778 and evaluation of their DNMT inhibitory activity
Leroy, M.; Mélin, L.; LaPlante, S. R.; Medina-Franco, J. L.; Gagnon, A. Bioorg. Med. Chem. Lett. 2019, 29 (6), 826–831
64. Fragment‐Based Phenotypic Lead Discovery: Cell‐Based Assay to Target Leishmaniasis
Ayotte, Y.; Bilodeau, F.; Descoteaux, A.; LaPlante, S. R. ChemMedChem 2018, 13 (14), 1377–1386.
63. Revealing dye and dye-drug aggregation into nano-entities using NMR
Murugesan, J. R.; Shahout, F.; Dlim, M.; Langella, M. M.; Cuadra-Foy, E.; Forgione, P.; LaPlante, S. R. Dye. Pigment. 2018, 153, 300–306.
62. NMR strategies to support medicinal chemistry workflows for primary structure determination
Oguadinma, P.; Bilodeau, F.; LaPlante, S. R. Bioorg. Med. Chem. Lett. 2017, 27 (2), 242–247.
61. The Rise of Academia-Pharma Partnerships for Discovering New Chemical Matter for Future Drugs
LaPlante, S; Bilodeau, F. EC Microbiology 4.5 (2016): 756-758
60. Aligning Potency and Pharmacokinetic Properties for Pyridine-Based NCINIs
Fader, LD; Bailey, M; Beaulieu, E; Bilodeau, F; Bonneau, P; Bousquet, Y; Carson, RJ; Chabot, C; Coulombe, R; Duan, J; Fenwick, C; Garneau, M; Halmos, T; Jakalian, A; James, C; Kawai, SH; Landry, S; LaPlante, S ; Mason, SW; Morin, S; Rioux, N; Simoneau, B; Surprenant, S; Thavonekham, B; Thibeault, C; Trinh, T; Tsantrizos, Y; Tsoung, J; Yoakim, C; Wernic, D
ACS Med Chem Lett. (2016) 7(8), 797-801.
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59. Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity
Beaulieu, PL; Bolger, G; Deon, D; Duplessis, M; Fazal, G; Gagnon, A; Garneau, M; LaPlante, S ; Stammers, T; Kukolj, G; Duan, J. Bioorg Med Chem Lett. (2015) 25(5),1140-5.
58. Conformation-Based Restrictions and Scaffold Replacements in the Design of HCV Polymerase Inhibitors: Discovery of Deleobuvir (BI 207127)
LaPlante, Steven R.; Bos, M; Brochu, C; Chabot, C; Coulombe, R; Gillard, JR.; Jakalian, A; Poirier, M; Rancourt, J; Stammers, T; Thavonekham, B; Beaulieu, PL.; Kukolj, G; Tsantrizos, YS. J. Med. Chem., (2014) 57, 1845-1854. Special HCV therapies issue.
57. Ligand Bioactive Conformation Plays a Critical Role in the Design of Drugs That That Target the Hepatitis C Virus NS3 Protease
LaPlante, Steven R.; Nar, Herbert; Lemke, Christopher; Jakalian, Araz; Aubry, Norman; Kawai, Stephen J. Med. Chem., (2014) 57, 1777-1789. Special HCV therapies issue.
56. Integrated Strategies for Identifying Leads that Target the NS3 of the Hepatitis C Virus
LaPlante, Steven R.; Padyana, Anil; Abeywardnae, Asitha; Bonneau, Pierre R; Cartier, Mireille; Colombe, Rene; Jakalian, Araz; Jones, Jessi; Li, Xiang; Liang, Shuang; McKercher, Ginette; White, Peter W; Zhang, Qiang; Taylor, Steven J., J. Med. Chem., (2014) 57, 2074-2090. Special HCV therapies issue.
55. Enantiomeric Atropisomers Inhibit HCV Polymerase and/or HIV Matrix: Characterizing Hindered Bond Rotations and Target Selectivity
LaPlante, Steven R.; Forgione, Pat; Boucher, Colette; Coulombe, René; Gillard, James; Hucke, Oliver; Jakalian, Araz; Joly, Marc-André; Kukolj, George; Lemke, Christopher; McCollum, Robert; Titolo, Steve; Beaulieu, Pierre L.; Stammers, Timothy,
J. Med. Chem., (2014) 57, 1944-1951. Special HCV therapies issue.
54. Discovery of BI 224436, a Non-Catalytic Site Integrase Inhibitor (NCINI) of HIV-1
Fader, Lee D.; Amad, Ma’an; Bailey, Murray D.; Bethell, Richard; Bhardwaj, Punit K.; Bilodeau, François; Bonneau, Pierre; Bös, Michael; Bousquet, Yves; Brochu, Christian; Carson, Rebekah; Chabot, Catherine; Cordingley, Michael; Coulombe, René; Duan, Jianmin; Edwards, Paul; Faucher, Anne-Marie; Fenwick, Craig; Garneau, Michel; Halmos, Ted; Jakalian, Araz; Kawai, Stephen; Landry, Serge; LaPlante Steven R.; Malenfant, Eric; Mason, Steve; Morin, Sébastien; Parisien, Mathieu; Pesant, Marc; Poupart, Marc-André; Schroeder, Patricia; Simoneau, Bruno; Tsantrizos, Youla; Wernic, Dominik; Yoakim, Christiane. ACS Med. Chem. Lett. (2014) 5, 422-427.
53. Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic-Site Integrase Inhibitor
Fenwick, Craig; Amad, Ma'an; Bailey, Murray D.; Bethell, Richard; Bös, Michael, Bonneau, Pierre; Cordingley, Michael; Coulombe, René; Duan, Jianmin; Edwards, Paul; Fader, Lee D.; Faucher, Anne-Marie; Garneau, Michel; Jakalian, Araz; Kawai, Stephen; Lamorte, Louie; LaPlante Steven R.; Luo, Laibin; Mason, Steve; Poupart, Marc-André; Rioux, Nathalie; Schroeder, Patricia; Simoneau, Bruno; Tremblay, Sonia; Tsantrizos, Youla, Witvrouw, Myriam; Yoakim, Christiane
Antimicrobial Agents and Chemotherapy, (2014), 56, 17, 7073–7083.
52. Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV
Fader, Lee D.; Carson, Rebekah; Morin, Sébastien; Bilodeau, François; Chabot, Catherine; Halmos, Ted; Bailey, Murray D.; Kawai, Stephen H.; Coulombe, René; LaPlante Steven R.; Mekhssian, Kevork; Jakalian, Araz; Garneau, Michel; Duan, Jianmin; Mason, Stephen W.; Simoneau, Bruno; Fenwick, Craig; Tsantrizos, Youla; Yoakim, Christiane. ACS Med. Chem. Lett., (2014), 5, 711–716.
51. Monitoring Drug Self-Aggregation and Potential for Promiscuity in Off-Target In Vitro Pharmacology Screens by a Practical NMR Strategy
LaPlante, Steven R.; Aubry, Norman; Bolger, Gordon; Bonneau, Pierre; Carson, Rebekah; Coulombe, René; Sturino, Claudio; Beaulieu Pierre L., J. Med. Chem., (2013), 56, 17, 7073–7083.
50. Compound Aggregation in Drug Discovery: Implementing a Practical NMR Assay for Medicinal Chemists
LaPlante, Steven R.; Carson, Rebekah; Gillard, James; Aubry, Norman; Coulombe, René; Bordeleau, Sylvain; Bonneau, Pierre; Little, Michael; O’Meara, Jeff; Beaulieu, Pierre L., J. Med. Chem., (2013), 56, 12, 5142–5150.
49. N- versus O-alkylation: Utilizing NMR Methods to Establish Reliable Primary Structure Determinations for Drug Discovery
LaPlante, Steven R.; Bilodeau, François; Aubry, Norman; Gillard, James R.; O’Meara, Jeff; Coulombe, René, Bioorganic & Medicinal Chemistry Letters, (2013), 23, 4663-4668
48. Anthranilic Acid-based Thumb Pocket 2 HCV NS5B polymerase Inhibitors with Sub-micromolar Potency in the Cell-based Replicon Assay
Stammers, Timothy A.; Coulombe, René; Duplessis, Martin; Fazal, Gulrez; Gagnon, Alexandre; Garneau, Michel; Goulet, Sylvie; Jakalian, Araz; LaPlante, Steven R.; Rancourt, Jean; Thavonekham, Bounkham; Wernic, Dominik; Kukolj, George; Beaulieu, Pierre L., Bioorganic & Medicinal Chemistry Letters, (2013) 23, 6879-6885.
47. Identification of Benzofurano[3,2-d]pyrimidin-2-ones, a New Series of HIV-1 Nucleotide-competing Reverse Transcriptase Inhibitors
Tremblay, Martin; Bethell, Richard C.; Cordingley, Michael G.; DeRoy, Patrick; Duan, Jianmin; Duplessis, Martin; Edwards, Paul J.; Faucher, Anne-Marie; Halmos, Ted; James, Clint A.; Kuhn, Cyrille; Lacoste, Jean-Éric; Lamorte, Louie; LaPlante Steven R.; Malenfant, Éric; Minville, Joannie; Morency, Louis; Morin, Sébastien; Rajotte, Daniel; et al. Bioorganic & Medicinal Chemistry Letters, (2013) 23, 9, 2775-2780
46. Discovery of the First Thumb Pocket 1 NS5B Polymerase Inhibitor (BILB 1941) with Demonstrated Antiviral Activity in Patients Chronically Infected with Genotype 1 Hepatitis C Virus (HCV)
Beaulieu, Pierre L.; Bos, Michael; Cordingley, Michael G.; Chabot, Catherine; Fazal, Gulrez; Garneau, Michel; Gillard, James R.; Jolicoeur, Eric; LaPlante, Steven R.; McKercher, Ginette. Journal of Medicinal Chemistry (2012), 55, 17, 7650-7666
45. Revealing Atropisomer Axial Chirality in Drug Discovery
LaPlante, Steven R.; Edwards, Paul J.; Fader, Lee D.; Jakalian, Araz; Hucke, Oliver. ChemMedChem (2011), 6, 3, 505-513.
44. Importance of Ligand Bioactive Conformation in the Discovery of Potent Indole-Diamide Inhibitors of the Hepatitis C Virus NS5B
LaPlante, Steven R.; Gillard, James R.; Jakalian, Araz; Aubry, Norman; Coulombe, Rene; Brochu, Christian; Tsantrizos, Youla S.; Poirier, Martin; Kukolj, George; Beaulieu, Pierre L. Journal of the American Chemical Society (2010), 132, 43, 15204-15212.
43. The Effect of the P1 Side Chain on the Binding of Optimized Carboxylate and Activated Carbonyl Inhibitors of the Hepatitis C Virus NS3 Protease
Kawai, Stephen H.; LaPlante, Steven R.; Llinas-Brunet, Montse; Hucke, Oliver. Future Medicinal Chemistry (2010), 2, 7, 1073-1081.
42. Dimethylthiazolidine Carboxylic Acid as a Rigid P3 Unit in Inhibitors of Serine Proteases: Application to Two Targets
Kawai, Stephen H.; Aubry, Norman; Duceppe, Jean-Simon; Llinas-Brunet, Montse; LaPlante, Steven R. Chemical Biology & Drug Design (2009), 74, 5, 517-522.
41. The Use of Chemical Double-mutant Cycles in Biomolecular Recognition Studies: Application to HCV NS3 Protease Inhibitors
Kawai, Stephen H.; Bailey, Murray D.; Halmos, Ted; Forgione, Pat; LaPlante, Steven R. ; Llinas-Brunet, Montse; Naud, Julie; Goudreau, Natalie. ChemMedChem (2008), 3, 11, 1654-1657.
40. Scaffold Hopping in the Rational Design of Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors
O'Meara, Jeff A.; Jakalian, Araz; LaPlante, Steven R.; Bonneau, Pierre R.; Coulombe, Rene; Faucher, Anne-Marie; Guse, Ingrid; Landry, Serge; Racine, Jennifer; Simoneau, Bruno; Bioorganic & Medicinal Chemistry Letters (2007), 17(12), 3362-3366.
39. Quantifying Trifluoroacetic Acid as a Counterion in Drug Discovery by 19F NMR and Capillary Electrophoresis
Little, Michael J.; Aubry, Norman; Beaudoin, Marie-Eve; Goudreau, Nathalie; LaPlante, Steven R. Journal of Pharmaceutical and Biomedical Analysis (2007), 43, 4, 1324-1330.
38. Improved Replicon Cellular Activity of non-nucleoside Allosteric Inhibitors of HCV NS5B Polymerase: From Benzimidazole to Indole Scaffolds
Beaulieu, Pierre L.; Gillard, James; Bykowski, Darren; Brochu, Christian; Dansereau, Nathalie; Duceppe, Jean-Simon; Hache, Bruno; Lagace, Lisette; LaPlante, Steven; et al. Bioorganic & Medicinal Chemistry Letters (2006), 16, 19, 4987-4993.
37. Liquid Cooling of a High-density Computer Cluster
LaPlante, Steven R.; Cavanaugh, Chuck; Porter, Don; Aboumrad, B. (Sam); Levesque, Patrick; Rosa, Louis; Aubry, Norman; Johnston, Jamie. Electronics Cooling (2006) November issue.
36. RCM of Tripeptide Dienes Containing a Chiral Vinylcyclopropane Moiety: Impact of Different Ru-Based Catalysts on the Stereochemical Integrity of the Macrocyclic Products
Poirier, Martin; Aubry, Norman; Boucher, Colette; Ferland, Jean-Marie; LaPlante, Steve; Tsantrizos, Youla S. Journal of Organic Chemistry (2005), 70, 26, 10765-10773.
35. Drug Design: Binding Mode Determination of Benzimidazole Inhibitors of the Hepatitis C Virus RNA Polymerase by a Structure and Dynamics Strategy
LaPlante, Steven R.; Jakalian, Araz; Aubry, Norman; Bousquet, Yves; Ferland, Jean-Marie; Gillard, James; Lefebvre, Sylvain; Poirier, Martin; Tsantrizos, Youla S.; Kukolj, George; Angewandte Chemie, International Edition (2004), 43, 33, 4306-4311.
34. Changes in Drug 13C NMR Chemical Shifts as a Tool for Monitoring Interactions With DNA
Boudreau, Eilis; Pelczer, Istvan; Borer, Philip N.; Heffron, Gregory; LaPlante, Steven R. Biophysical Chemistry (2004), 109, 3, 333-344.
33. Specific Inhibitors of HCV Polymerase Identified Using an NS5B With Lower Affinity for Template/primer Substrate
McKercher, Ginette; Beaulieu, Pierre L.; Lamarre, Daniel; LaPlante, Steven; Lefebvre, Sylvain; Pellerin, Charles; Thauvette, Louise; Kukolj, George. Nucleic Acids Research (2004), 32, 2, 422-431.
32. Non-nucleoside Inhibitors of the Hepatitis C Virus NS5B Polymerase: Discovery and Preliminary SAR of Benzimidazole Derivatives
Beaulieu, Pierre L.; Bos, Michael; Bousquet, Yves; Fazal, Gulrez; Gauthier, Jean; Gillard, James; Goulet, Sylvie; LaPlante, Steven; Poupart, Marc-Andre; Lefebvre, Sylvain; Bioorganic & Medicinal Chemistry Letters (2004), 14, 1, 119-124.
31. An NS3 Protease Inhibitor with Antiviral Effects in Humans Infected with Hepatitis C Virus
Lamarre, Daniel; Anderson, Paul C.; Bailey, Murray; Beaulieu, Pierre; Bolger, Gordon; Bonneau, Pierre; Boes, Michael; Cameron, Dale R.; Cordingley, Michael G.; LaPlante, Steven. Nature (London, United Kingdom) (2003), 426, 6963, 186-189 and 426, 6964, 314.
30. Macrocyclic Inhibitors of the NS3 Protease as Potential Therapeutic Agents of Hepatitis C Virus Infection
Tsantrizos, Youla S.; Bolger, Gordon; Bonneau, Pierre; Cameron, Dale R.; Goudreau, Nathalie; Kukolj, George; LaPlante, Steven R.; Llinas-Brunet, Montse; Nar, Herbert; Lamarre, Daniel. Angewandte Chemie, International Edition (2003), 42, 12, 1356-1360.
29. Changes in 13C NMR Chemical Shifts of DNA as a Tool for Monitoring Drug Interactions
LaPlante, S. R.; Borer, P. N. Biophysical Chemistry (2001), 90, 3, 219-232.
28. Transferred 13C T1 Relaxation at Natural Isotopic Abundance: A Practical Method for Determining Site-Specific Changes in Ligand Flexibility upon Binding to a Macromolecule
LaPlante, Steven R.; Aubry, Norman; Deziel, Robert; Ni, Feng; Xu, Ping. Journal of the American Chemical Society (2000), 122, 50, 12530-12535.
27. NMR Line-broadening and Transferred NOESY as a Medicinal Chemistry Tool for Studying Inhibitors of the Hepatitis C Virus NS3 Protease Domain
LaPlante, S. R.; Aubry, N.; Bonneau, P. R.; Kukolj, G.; Lamarre, D.; Lefebvre, S.; Li, H.; Llinas-Brunet, M.; Plouffe, C.; Cameron, D. R. Bioorganic & Medicinal Chemistry Letters (2000), 10, 20, 2271-2274.
26. Solution Structure of Substrate-based Ligands when Bound to Hepatitis C Virus NS3 Protease Domain
LaPlante, Steven R.; Cameron, Dale R.; Aubry, Norman; Lefebvre, Sylvain; Kukolj, George; Maurice, Roger; Thibeault, Diane; Lamarre, Daniel; Llinas-Brunet, Montse Journal of Biological Chemistry (1999), 274, 26, 18618-18624.
25. Characterization of the Human Cytomegalovirus Protease As an Induced-Fit Serine Protease and the Implications to the Design of Mechanism-Based Inhibitors
LaPlante, Steven R.; Bonneau, Pierre R.; Aubry, Norman; Cameron, Dale R.; Deziel, Robert; Grand-Maitre, Chantal; Plouffe, Celine; Tong, Liang; Kawai, Stephen H. Journal of the American Chemical Society (1999), 121, 13, 2974-2986.
24. Inhibition of Human Cytomegalovirus Protease by Monocyclic β-Lactam Derivatives: Kinetic Characterization Using a Fluorescent Probe
Bonneau, Pierre R.; Hasani, Firoz; Plouffe, Celine; Malenfant, Eric; LaPlante, Steve R.; Guse, Ingrid; Ogilvie, William; Plante, Raymond; Davidson, Walter; Hopkins, Jerry L.; Journal of the American Chemical Society (1999), 121, 13, 2965-2973.
23. The Conformation of a Peptidyl Methyl Ketone Inhibitor Bound to the Human Cytomegalovirus Protease
LaPlante, Steven R.; Cameron, Dale R.; Aubry, Norman; Bonneau, Pierre R.; Deziel, Robert; Grand-Maitre, Chantal; Ogilvie, William W.; Kawai, Stephen H. Angewandte Chemie, International Edition (1998), 37, 19, 2729-2732.
22. Peptide-based Inhibitors of the Hepatitis C Virus Serine Protease
Llinas-Brunet, Montse; Bailey, Murray; Fazal, Gulrez; Goulet, Sylvie; Halmos, Ted; LaPlante, Steven; Maurice, Roger; Poupart, Marc-Andre; Thibeault, Diane; et al. Bioorganic & Medicinal Chemistry Letters (1998), 8, 13, 1713-1718.
21. Human Cytomegalovirus Protease Complexes Its Substrate Recognition Sequences in an Extended Peptide Conformation
LaPlante, Steven R.; Aubry, Norman; Bonneau, Pierre R.; Cameron, Dale R.; Lagace, Lisette; Massariol, Marie-Josee; Montpetit, Helene; Plouffe, Celine; Kawai, Stephen H.; Fulton, Bruce D.; et al. Biochemistry (1998), 37, 27, 9793-9801.
20. Evidence of a Conformational Change in the Human Cytomegalovirus Protease upon Binding of Peptidyl-Activated Carbonyl Inhibitors
Bonneau, Pierre R.; Grand-Maitre, Chantal; Greenwood, Daniel J.; Lagace, Lisette; LaPlante, Steven R.; Massariol, Marie-Josee; Ogilvie, William W.; O'Meara, Jeff; Kawai, Stephen H. Biochemistry (1997), 36, 41, 12644-12652.
19. Several Polyhydroxymonoamide Renin Inhibitors Assume Similar Conformations in the Unbound and Renin-bound States
LaPlante, Steven R.; Tong, Liang; Aubry, Norman; Pav, Susan; Jung, Grace; Anderson, Paul C. International Journal of Peptide & Protein Research (1996), 48, 5, 401-410.
18. High Resolution Crystal Structures of Recombinant Human Renin in Complex with Polyhydroxymonoamide Inhibitors
Tong, Liang; Pav, Susan; Lamarre, Daniel; Pilote, Louise; LaPlante, Steven; Anderson, Paul C.; Jung, Grace
Journal of Molecular Biology (1995), 250, 2, 211-22.
17. The Critical C-terminus of the Small Subunit of Herpes Simplex Virus Ribonucleotide Reductase is Mobile and Conformationally Similar to C-terminal Peptides
LaPlante, Steven R.; Aubry, Norman; Liuzzi, Michel; Thelander, Lars; Ingemarson, Rolf; Moss, Neil International Journal of Peptide & Protein Research (1994), 44, 6, 549-55.
16. 13C-NMR Relaxation in Three DNA Oligonucleotide Duplexes: Model-Free Analysis of Internal and Overall Motion
Borer, Philip N.; LaPlante, Steven R.; Kumar, Anil; Zanatta, Nilo; Martin, Amy; Hakkinen, Anna; Levy, George C.
Biochemistry (1994), 33, 9, 2441-50.
15. 13C-NMR of the Deoxyribose Sugars in Four DNA Oligonucleotide Duplexes: Assignment and Structural Features
LaPlante, Steven R.; Zanatta, Nilo; Hakkinen, Anna; Wang, Andrew; Borer, Philip N. Biochemistry (1994), 33, 9, 2430-40.
14. α-Cobratoxin: Proton NMR Assignment and Solution Structure
Le Goas, Remi; LaPlante, Steven R.; Mikou, Afaf; Delsuc, Marc Andre; Guittet, Eric; Robin, Michel; Charpentier, Isabelle; Lallemand, Jean-Yves Biochemistry (1992), 31, 20, 4867-75.
13. Toxin III of the Scorpion Androctonus Australis Hector: Proton Nuclear Magnetic Resonance Assignments and Secondary Structure
Mikou, Afaf; LaPlante, Steven R.; Guittet, Eric; Lallemand, Jean Yves; Martin-Eau Claire, Marie France; Rochat, Herve
Journal of Biomolecular NMR (1992), 2, 1, 57-70.
12. Insight Into Protein Nuclear Magnetic Resonance Research
Stoven, V.; Lallemand, J. Y.; Abergel, D.; Bouaziz, S.; Delsuc, M. A.; Ekondzi, A.; Guittet, E.; LaPlante, S.; Le Goas, R.; .
Biochimie (1990), 72, 8, 531-5.
11. Rapid Determination and NMR Assignments of Antiparallel Sheets and Helixes of a Scorpion and a Cobra Toxin
LaPlante, Steven R.; Mikou, Afaf; Robin, Michel; Guittet, Eric; Delsuc, Marc Andre; Charpentier, Isabelle; Lallemand, Jean Yves International Journal of Peptide & Protein Research (1990), 36, 3, 227-30.
10. Preliminary Structure Determination of Two Roxins Using NMR Data
Mikou, A.; LaPlante, S.; Le Goas, R.; Delsuc, M. A.; Charpentier, I.; Guittet, E.; Lallemand, J. Y.
Studies in Physical and Theoretical Chemistry (1990), 71, (Modell. Mol. Struct. Prop.), 685-93.
9. A Toxin of Cobra Venom: Methods for Structure Determination by NMR
Guittet, E.; Delsuc, M.; LaPlante, S.; Mikou, A.; Robin, M.; Stoven, V.; Lallemand, J. Y.
Bulletin of Magnetic Resonance (1989), 11, 3-4, 284-9.
8. Conformational Analysis of DNA Oligonucleotides Using Carbon-13 NMR and Proton NMR
LaPlante, Steven R.
Ph.D. Thesis, Syracuse University, (1988), 1-252.
7. Actinomycin D-induced DNase I Cleavage Enhancement Caused by Sequence Specific Propagation of an Altered DNA Structure
Huang, Yao Qi; Rehfuss, Robert P.; LaPlante, Steven R.; Boudreau, Eilis; Borer, Philip N.; Lane, Michael J.
Nucleic Acids Research (1988), 16, 23, 11125-39.
6. Sequence Specific Carbon-13 NMR Assignment of Non-protonated Carbons in [d(TAGCGCTA)]2 Using Proton Detection
Ashcroft, Joseph; LaPlante, Steven R.; Borer, Philip N.; Cowburn, David Journal of the American Chemical Society (1989), 111, 1, 363-5.
5. Carbon-13 NMR of the Bases of Three DNA Oligonucleotide Duplexes: Assignment Methods and Structural Features
LaPlante, Steven R.; Boudreau, Eilis A.; Zanatta, Nilo; Levy, George C.; Borer, Philip N.; Ashcroft, Joseph; Cowburn, David
Biochemistry (1988), 27, 20, 7902-9.
4. Carbon-13 NMR Assignments of the Protonated Carbons of [d(TAGCGCTA)]2 by Two-dimensional Proton-detected Heteronuclear Correlation
LaPlante, Steven R.; Ashcroft, Joseph; Cowburn, David; Levy, George C.; Borer, Philip Journal of Biomolecular Structure & Dynamics (1988), 5, 5, 1089-99.
3. Hydrogen-bonding Effects and Carbon-13 NMR of the DNA Double Helix
Borer, Philip N.; LaPlante, Steven R.; Zanatta, Nilo; Levy, George C. Nucleic Acids Research (1988), 16, (5, Pt. B), 2323-32.
2. Analysis of DNA and DNA-lexitropsin Interaction Using Multinuclear NMR and Molecular Dynamics
Borer P N; LaPlante S R; Wang S; Levy G C Biochemical pharmacology (1988), 37, 9, 1821-2.
1. Actinomycin D Facilitates Transition of AT Domains in Molecules of Sequence (AT)nAGCT(AT)n to a DNase I Detectable Alternating Structure
Lane, Michael J.; LaPlante, Steven; Rehfuss, Robert P.; Borer, Philip N.; Cantor, Charles R. Nucleic Acids Research (1987), 15, 2, 839-52.